Predicting drug-induced QT prolongation and torsades de pointes
نویسندگان
چکیده
منابع مشابه
Drug-Induced QT Prolongation And Torsades de Pointes.
Torsades de pointes (TdP)-an uncommon but life-threatening polymorphic ventricular tachycardia-is almost always drug induced. The authors describe the causes, risk factors, symptoms, diagnosis, and treatment of TdP.
متن کاملDrug Induced Qt Prolongation and Torsades De Pointes
Correspondence to: Dr Yee Guan Yap, Department of Cardiological Sciences, St George’s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK; [email protected] _________________________ I n 1966, Francois Dessertenne described a specific electrocardiographic form of polymorphic ventricular tachycardia, which he termed ‘‘torsades de pointes’’ (TdP). w2 The word ‘‘torsades’’ refers to an ornam...
متن کاملDothiepin, Qt Prolongation and Torsades De Pointes
A case is reported of electrocardiographic QT prolongation that was presumbty familial in origin. Torsades de points developed in association with the use ofdothinepin, despite the pmscription of a low dose of this drug.
متن کاملProbucol-induced QT prolongation and torsades de pointes.
Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventri...
متن کاملDrug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram.
BACKGROUND Although QT prolongation is associated with increased risk of torsade de pointes (TdP), the precise relationship is not well defined. AIM To evaluate the performance of a QT nomogram in assessing the risk of TdP from QT-RR combinations. DESIGN Systematic review. METHODS We systematically searched MEDLINE/EMBASE for cases of drug-induced TdP. Controls were patients taking non-ca...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2016
ISSN: 0022-3751
DOI: 10.1113/jp270526